What to Know
Hepatitis C Symptoms
Hepatitis C symptoms differ between the acute and chronic phases. During the first few weeks to months after infection, most people have no symptoms. Only around one in three develop symptoms such as fatigue, nausea, reduced appetite, abdominal discomfort or, occasionally, jaundice (yellowing of the skin and eyes). Symptoms are often mild and nonspecific, so acute infection is rarely diagnosed. Some people clear the virus naturally during this phase.
Around 75% of people develop chronic hepatitis C, which can remain symptom-free for years or decades while liver damage gradually accumulates. Symptoms may not appear for 20–30 years and, when they do, often reflect established liver disease rather than the infection itself.
Serious complications include liver scarring (fibrosis), which can progress to cirrhosis, causing fatigue, abdominal fluid retention, easy bruising and, in advanced cases, confusion. Chronic hepatitis C also increases the risk of liver cancer and is a major cause of liver transplantation in Australia. These complications are largely preventable with timely diagnosis and treatment.
Hepatitis C Diagnosis and Treatment
Hepatitis C is diagnosed with two blood tests. An antibody test detects past exposure, while an HCV RNA test confirms whether the virus is currently present. RNA testing is also used after previous treatment or clearance and following recent potential exposure.
Active hepatitis C can be cured in more than 95% of people with direct-acting antivirals. In Australia, these medicines are available through the PBS and can be prescribed by GPs or specialists. Treatment is usually once daily for 8–12 weeks, is generally well tolerated, and includes pan-genotypic options such as glecaprevir/pibrentasvir and sofosbuvir/velpatasvir. Cure is confirmed by an HCV RNA test 12 weeks after treatment.
Treatment is beneficial even when liver fibrosis has already developed, as clearing the virus can prevent further damage and reduce the risk of complications. People with advanced fibrosis or cirrhosis may need ongoing liver monitoring even after cure.
Anyone concerned about exposure through an overseas medical procedure, injecting drug use, unsterile tattoos or piercings, or other blood contact should speak with a GP about testing. Early diagnosis allows treatment before significant liver damage develops.
Hepatitis C Prevention
There is no vaccine for hepatitis C, so prevention relies on avoiding blood-to-blood contact. For Australian travellers, avoid tattoos, piercings and elective medical or dental procedures overseas unless sterile, single-use equipment is used. Where infection-control standards are uncertain, consider delaying elective procedures until returning to Australia.
Injecting drug use is a major route of hepatitis C transmission. Never share needles, syringes or other injecting equipment, and use new or sterile equipment every time. Sexual transmission is less common but can occur, particularly where blood is present. Condoms reduce this risk. People taking HIV PrEP should have regular hepatitis C testing as part of routine monitoring.
If you may have been exposed overseas, speak with a GP about testing after returning to Australia. Most infections cause no obvious symptoms, so a blood test is needed. Confirmed infection can usually be cured with a short course of well-tolerated tablets.