What to Know
Symptoms of Viral haemorrhagic fevers
Viral haemorrhagic fevers (VHFs) share several early symptoms, though severity varies by virus. Illness usually develops up to 9 days for Marburg virus disease, up to 13 days for Crimean-Congo haemorrhagic fever, and up to 21 days for Ebola virus disease and Lassa fever.
Early symptoms can begin gradually and may include fever, severe headache, muscle aches, and general fatigue. Other possible symptoms include chest pain, cough, abdominal pain, diarrhoea, conjunctivitis, facial swelling, and jaundice. Because these symptoms overlap with common illnesses such as malaria, typhoid, and influenza, VHF may not be suspected initially, particularly in returning travellers.
As illness progresses, some people recover whilst some develop bleeding of the nose or gums, vomiting, coughing blood, bruising and internal bleeding. Severe disease may result in multi-organ failure and death. Not all VHFs cause bleeding, and many cases, particularly Lassa fever, may be mild or even asymptomatic. Mortality varies widely, from around 1–15% in hospitalised Lassa fever cases to 50–90% in Ebola outbreaks.
People who recover from Ebola may experience long-term complications, including fatigue, joint and muscle pain, eye problems, and neurological symptoms lasting months or years.
Diagnosis and treatment of Viral haemorrhagic fevers
Diagnosis requires a high level of clinical suspicion and careful attention to travel and exposure history. Because early symptoms resemble many common infections, VHF should be considered in anyone who has been in a risk area and develops fever within the relevant incubation period.
Diagnosis is confirmed with specialised blood testing, usually PCR with or without serology, performed in high-biosafety public health laboratories.
If VHF is suspected, clinicians must notify public health authorities immediately by phone before test confirmation, so infection control measures can begin straight away. Patients require hospital assessment, and specialist infectious disease teams guide testing, isolation, and management.
Treatment depends on the type of virus, which may involve medications and intensive supportive care such as fluids, organ support and treatment of complications.
Prevention of Viral haemorrhagic fevers
Prevention focuses on avoiding exposure to animal reservoirs, vectors, and infected body fluids. Travellers to high-risk areas should avoid raw or undercooked meat, particularly from bats, primates, or monkeys, and maintain strict hand hygiene. Insect precautions such as repellent and protective clothing help reduce tick and mosquito exposure, and contact with rodents should be avoided.
Cave or mine visits in regions with Ebola or Marburg risk should be avoided during outbreaks due to potential exposure to infected bats. In areas where Crimean-Congo haemorrhagic fever occurs, those working with animals should avoid contact with blood or tissues and use appropriate protective equipment.
Anyone returning from an outbreak area who develops fever should call a doctor or hospital before attending in person, clearly stating travel history and symptoms. If emergency services are required, this information should be given before arrival. Early disclosure of travel history is critical for rapid diagnosis, isolation, and safe management.
If a VHF is diagnosed, preventing transmission includes isolation until no longer infectious, condom use after recovery until medically cleared, and following all infection-control advice, including mask use where recommended.